Mods that make significant changes to the landscape / terrain This can be applied for FO3, NV, TTW, or even FO4. Here is an incredibly easy way to sort your load offset. Using LOOT will not magically fix your game. Reason being is that it’s no better than a pinch of non magical fairy dust. Whilst LOOT is a powerful tool for modding many Bethesda titles, it shouldn't be used as a crutch for bad modding Hence, it's better to learn how to maintain your setup yourself, rather than having a program try do it for you. You should not use LOOT with TTW or FNV, and this is how you manage load order effectivelly.
The following is a Load Order guide composed of tips from Tgspy (Frontier Dev), Roy Batty (TTW Dev), and the XEdit Team.